Genotypic and phenotypic characterization of drug-resistant Mycobacterium tuberculosis isolates from rural districts of the Western Cape Province of South Africa

J Clin Microbiol. 2004 Feb;42(2):891-4. doi: 10.1128/JCM.42.2.891-894.2004.

Abstract

Genotypic and phenotypic analysis of drug-resistant Mycobacterium tuberculosis isolates from the Western Cape Province of South Africa showed that drug resistance is widespread and recently transmitted. Multidrug-resistant (MDR) isolates comprise 40% of this collection, and a large pool of isoniazid monoresistance may be a future source of MDR tuberculosis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • DNA Primers
  • Drug Resistance, Bacterial / genetics*
  • Drug Resistance, Multiple / genetics*
  • Genotype
  • Geography
  • Humans
  • Mycobacterium tuberculosis / classification
  • Mycobacterium tuberculosis / drug effects
  • Mycobacterium tuberculosis / genetics*
  • Mycobacterium tuberculosis / isolation & purification*
  • Phenotype
  • Rural Population
  • South Africa / epidemiology
  • Tuberculosis / diagnosis*
  • Tuberculosis / epidemiology
  • Tuberculosis / transmission

Substances

  • DNA Primers