Abstract
A new derivative of strychnopentamine was isolated from the leaves of Strychnos usambarensis. This compound, named chrysopentamine, was identified by detailed spectroscopic methods (UV, IR, HR-ESI-MS, 1D and 2D NMR). Chrysopentamine presented an original hydroxy substitution on C-14 and an aromatization of the ring D of strychnopentamine leading to anhydronium base properties and exhibited strong antiplasmodial properties (IC (50) less than 1 microM).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antimalarials / chemistry
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Antimalarials / pharmacology*
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Heterocyclic Compounds, 4 or More Rings / chemistry
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Heterocyclic Compounds, 4 or More Rings / pharmacology*
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Inhibitory Concentration 50
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Magnetic Resonance Spectroscopy
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Parasitic Sensitivity Tests
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Phytotherapy*
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Plant Leaves
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Plasmodium falciparum / drug effects*
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Pyrrolidines / chemistry
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Pyrrolidines / pharmacology*
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Strychnos*
Substances
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Antimalarials
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Heterocyclic Compounds, 4 or More Rings
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Pyrrolidines
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chrysopentamine