Chrysopentamine, an antiplasmodial anhydronium base from Strychnos usambarensis leaves

Planta Med. 2004 Jan;70(1):72-6. doi: 10.1055/s-2004-815461.

Abstract

A new derivative of strychnopentamine was isolated from the leaves of Strychnos usambarensis. This compound, named chrysopentamine, was identified by detailed spectroscopic methods (UV, IR, HR-ESI-MS, 1D and 2D NMR). Chrysopentamine presented an original hydroxy substitution on C-14 and an aromatization of the ring D of strychnopentamine leading to anhydronium base properties and exhibited strong antiplasmodial properties (IC (50) less than 1 microM).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antimalarials / chemistry
  • Antimalarials / pharmacology*
  • Heterocyclic Compounds, 4 or More Rings / chemistry
  • Heterocyclic Compounds, 4 or More Rings / pharmacology*
  • Inhibitory Concentration 50
  • Magnetic Resonance Spectroscopy
  • Parasitic Sensitivity Tests
  • Phytotherapy*
  • Plant Leaves
  • Plasmodium falciparum / drug effects*
  • Pyrrolidines / chemistry
  • Pyrrolidines / pharmacology*
  • Strychnos*

Substances

  • Antimalarials
  • Heterocyclic Compounds, 4 or More Rings
  • Pyrrolidines
  • chrysopentamine