Himalomycin A and B: isolation and structure elucidation of new fridamycin type antibiotics from a marine Streptomyces isolate

Rajendra P Maskey; Elisabeth Helmke; Hartmut Laatsch

doi:10.7164/antibiotics.56.942

Himalomycin A and B: isolation and structure elucidation of new fridamycin type antibiotics from a marine Streptomyces isolate

J Antibiot (Tokyo). 2003 Nov;56(11):942-9. doi: 10.7164/antibiotics.56.942.

Authors

Rajendra P Maskey¹, Elisabeth Helmke, Hartmut Laatsch

Affiliation

¹ Department of Organic Chemistry, University of Göttingen, Tammannstrasse 2, Göttingen D-37077, Germany.

PMID: 14763560
DOI: 10.7164/antibiotics.56.942

Abstract

In our screening of marine Streptomycetes for bioactive compounds, in addition to the known metabolites rabelomycin (1), fridamycin D (2b), N-benzylacetamide and N-(2'-phenylethyl)acetamide, two new anthracycline antibiotics designated as himalomycin A (2c) and B (2d) were isolated from the culture broth of the marine Streptomyces sp. isolate B6921. The structure of the new antibiotics was determined by comparison of the NMR data with those of fridamycin D (2b) and by detailed interpretation of mass, 1D and 2D NMR spectra.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anthracyclines / chemistry
Anthracyclines / isolation & purification*
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / isolation & purification*
Fermentation
Molecular Structure
Streptomyces

Substances

Anthracyclines
Anti-Bacterial Agents
himalomycin A
himalomycin B