InvB is required for type III-dependent secretion of SopA in Salmonella enterica serovar Typhimurium

Kristin Ehrbar; Siegfried Hapfelmeier; Bärbel Stecher; Wolf-Dietrich Hardt

doi:10.1128/JB.186.4.1215-1219.2004

InvB is required for type III-dependent secretion of SopA in Salmonella enterica serovar Typhimurium

J Bacteriol. 2004 Feb;186(4):1215-9. doi: 10.1128/JB.186.4.1215-1219.2004.

Authors

Kristin Ehrbar¹, Siegfried Hapfelmeier, Bärbel Stecher, Wolf-Dietrich Hardt

Affiliation

¹ Institute of Microbiology, ETH Zürich, 8092 Zürich, Switzerland.

Abstract

The Salmonella effector protein SopA is translocated into host cells via the SPI-1 type III secretion system (TTSS) and contributes to enteric disease. We found that the chaperone InvB binds to SopA and slightly stabilizes it in the bacterial cytosol and that it is required for its transport via the SPI-1 TTSS.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bacterial Proteins / genetics
Bacterial Proteins / metabolism*
Bacterial Proteins / physiology*
Cytosol / metabolism
Protein Transport
Salmonella typhimurium / metabolism*
Transcription, Genetic

Substances

Bacterial Proteins
invB protein, Salmonella
SopA protein, Bacteria