Abstract
Two types of IgG anti-DNA antibodies exhibiting DNA-hydrolyzing activity have been isolated from blood serum of patients with systemic lupus erythematosus. This DNase activity of antibodies differs from serum DNases by the non-processive mode, temperature resistance, pH optimum, and the rate of DNA hydrolysis. It is suggested that the anti-DNA antibody molecule possessing DNase activity contains two sites: one site determines specificity of antibody-DNA interaction, whereas the other is responsible for manifestation of the catalytic activity.
MeSH terms
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Antibodies, Antinuclear / immunology*
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Antibodies, Antinuclear / isolation & purification
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Antibodies, Antinuclear / metabolism*
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DNA / metabolism*
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Deoxyribonucleases / metabolism
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Humans
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Hydrogen-Ion Concentration
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Hydrolysis
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Immunoglobulin G / immunology*
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Immunoglobulin G / isolation & purification
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Immunoglobulin G / metabolism*
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Kinetics
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Lupus Erythematosus, Systemic / immunology*
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Lupus Erythematosus, Systemic / metabolism*
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Plasmids / metabolism
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Spectrometry, Fluorescence
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Temperature
Substances
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Antibodies, Antinuclear
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Immunoglobulin G
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DNA
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Deoxyribonucleases