Influence of nonexcitable cells on spiral breakup in two-dimensional and three-dimensional excitable media

Phys Rev E Stat Nonlin Soft Matter Phys. 2003 Dec;68(6 Pt 1):062902. doi: 10.1103/PhysRevE.68.062902. Epub 2003 Dec 31.

Abstract

We study spiral wave dynamics in the presence of nonexcitable cells in two-dimensional (2D) and three-dimensional (3D) excitable media, described by the Aliev-Panfilov model. We find that increasing the percentage of randomly distributed nonexcitable cells can prevent the breaking up of a spiral wave into a complex spatiotemporal pattern. We show that this effect is more pronounced in 2D than 3D excitable media. We explain the observed 2D vs 3D differences by a different dependence of the period and diastolic interval of the spiral wave on the percentage of nonexcitable cells in 2D and 3D excitable media.

MeSH terms

  • Animals
  • Arrhythmias, Cardiac
  • Biophysical Phenomena
  • Biophysics*
  • Diastole
  • Fibrosis
  • Humans
  • Models, Cardiovascular
  • Models, Statistical
  • Myocardium / pathology
  • Time Factors
  • Ventricular Fibrillation