Evaluation of the fully automated Bactec MGIT 960 system for the susceptibility testing of Mycobacterium tuberculosis to first-line drugs: a multicenter study

J Microbiol Methods. 2004 Feb;56(2):291-4. doi: 10.1016/j.mimet.2003.10.015.

Abstract

The accuracy of the Bactec MGIT 960 system for susceptibility testing of 177 clinical isolates of Mycobacterium tuberculosis to first line drugs (isoniazid, rifampicin, ethambutol and streptomycin) was compared with the agar reference method. The sensitivity, the ability to detect resistance, of the MGIT system was 100%, while the specificity, the ability to detect susceptibility, ranged from 98.6% to 100% for all drugs tested.

Publication types

  • Comparative Study
  • Evaluation Study
  • Multicenter Study

MeSH terms

  • Antitubercular Agents / pharmacology*
  • Drug Resistance, Multiple, Bacterial
  • Ethambutol / pharmacology
  • Humans
  • Isoniazid / pharmacology
  • Microbial Sensitivity Tests / methods*
  • Mycobacterium tuberculosis / drug effects*
  • Mycobacterium tuberculosis / growth & development
  • Mycobacterium tuberculosis / isolation & purification
  • Reagent Kits, Diagnostic
  • Rifampin / pharmacology
  • Sensitivity and Specificity
  • Streptomycin / pharmacology
  • Tuberculosis / microbiology

Substances

  • Antitubercular Agents
  • Reagent Kits, Diagnostic
  • Ethambutol
  • Isoniazid
  • Rifampin
  • Streptomycin