Since its discovery and characterization in western Canada in 1995, the distribution of post-weaning multisystemic wasting syndrome (PMWS) has grown and the syndrome is undoubtedly recognized worldwide. More recently, there is a heightened interest in several potentially related conditions including porcine dermatitis and nephropathy syndrome (PDNS), proliferative and necrotizing pneumonia (PNP), congenital tremors (CT-AII), perinatal myocarditis and reproductive failure. Although the causality of porcine circovirus type 2 (PCV2) has recently been proven [Vet. Pathol. 37 (2000) 254; J. Comp. Pathol. 122 (2000) 9; J. Vet. Diagn. Invest. 13 (2001) 185], PCV2 is present in both diseased and healthy pig populations. Furthermore, recent serologic studies have shown that there are no significant differences in PCV2 specific IgG titres between PMWS clinical and non-clinical herds (Harding et al., in press). Clearly, the transmission, epidemiology, and factors triggering clinical expression are poorly understood. With these uncertainties in mind, the objective of this paper is to review the clinical expression and emergence of PMWS and the potentially associated disease syndromes including PDNS.