Pituitary metastasis of follicular thyroid carcinoma

Horm Res. 2004;61(4):190-2. doi: 10.1159/000076387. Epub 2004 Jan 25.

Abstract

Objective: The case of a 60-year-old male patient with follicular thyroid cancer who developed a pituitary mass proved to be a metastasis from thyroid cancer.

Methods: Assessment with whole-body scan, ultrasound, computed tomography and thyroglobulin measurements.

Results: Despite surgery and repeated doses of radioiodine, the patient developed diplopia and ptosis of the right eyelid, along with increasing thyroglobulin levels. A pituitary mass was discovered, with no signs of pituitary deficiency. The mass was removed and found to consist of neoplastic cells immunohistochemically positive to thyroglobulin.

Conclusions: Distant metastases may develop in cases of follicular thyroid carcinoma, even after repeated doses of (131)I. Metastatic follicular thyroid carcinoma to the pituitary is a rare entity.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma, Follicular / complications
  • Adenocarcinoma, Follicular / metabolism
  • Adenocarcinoma, Follicular / pathology*
  • Adenocarcinoma, Follicular / secondary*
  • Adenocarcinoma, Follicular / surgery
  • Blepharoptosis / etiology
  • Diplopia / etiology
  • Humans
  • Immunohistochemistry
  • Male
  • Middle Aged
  • Pituitary Neoplasms / complications
  • Pituitary Neoplasms / metabolism
  • Pituitary Neoplasms / pathology*
  • Pituitary Neoplasms / secondary*
  • Pituitary Neoplasms / surgery
  • Thyroglobulin / metabolism*
  • Thyroid Neoplasms / pathology*

Substances

  • Thyroglobulin