Adhesins and invasins of pathogenic bacteria: a structural view

Hartmut H Niemann; Wolf Dieter Schubert; Dirk W Heinz

doi:10.1016/j.micinf.2003.11.001

Adhesins and invasins of pathogenic bacteria: a structural view

Microbes Infect. 2004 Jan;6(1):101-12. doi: 10.1016/j.micinf.2003.11.001.

Authors

Hartmut H Niemann¹, Wolf Dieter Schubert, Dirk W Heinz

Affiliation

¹ Department of Structural Biology, German Research Center for Biotechnology (GBF), Mascheroder Weg 1, 38124, Braunschweig, Germany.

PMID: 14738899
DOI: 10.1016/j.micinf.2003.11.001

Abstract

Adhesion and invasion of pathogenic bacteria represent the important initial step of infection. Pathogens utilize surface-located adhesins/invasins for specific interaction with host cell receptors. The three-dimensional structures of a number of adhesins/invasins show that many are elongated molecules containing domains commonly found in eukaryotic proteins. Similar folds are employed repeatedly to target different receptors.

Publication types

Review

MeSH terms

Adhesins, Bacterial / chemistry
Adhesins, Bacterial / physiology*
Animals
Bacteria / pathogenicity*
Bacterial Adhesion*
Bacterial Physiological Phenomena
Humans
Listeria monocytogenes / chemistry
Listeria monocytogenes / physiology
Models, Molecular
Structure-Activity Relationship
Virulence Factors / physiology*
Yersinia / chemistry
Yersinia / physiology

Substances

Adhesins, Bacterial
Virulence Factors
invasin, Yersinia