Three new oleanane-type triterpenes from Ludwigia octovalvis with cytotoxic activity against two human cancer cell lines

Chi-I Chang; Ching-Chuan Kuo; Jang-Yang Chang; Yueh-Hsiung Kuo

doi:10.1021/np030267m

Three new oleanane-type triterpenes from Ludwigia octovalvis with cytotoxic activity against two human cancer cell lines

J Nat Prod. 2004 Jan;67(1):91-3. doi: 10.1021/np030267m.

Authors

Chi-I Chang¹, Ching-Chuan Kuo, Jang-Yang Chang, Yueh-Hsiung Kuo

Affiliation

¹ Graduate Institute of Biotechnology, National Pingtung University of Science and Technology, Pingtung, Taiwan 912, Republic of China.

PMID: 14738395
DOI: 10.1021/np030267m

Abstract

Three new oleanane-type triterpenes, (23Z)-coumaroylhederagenin (1), (23E)-coumaroylhederagenin (2), and (3Z)-coumaroylhederagenin (3), together with two known triterpene acids, oleanolic acid and ursolic acid, have been isolated from the whole plant of Ludwigia octovalvis, and their structures have been elucidated by spectroscopic methods. All three new triterpenes showed significant cytotoxicity against two human tumor cell lines, namely, oral epidermoid carcinoma KB and colorectal carcinoma HT29, and gave IC(50) values in the range 1.2-3.6 microM.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / isolation & purification*
Antineoplastic Agents, Phytogenic / pharmacology
Cell Line, Tumor
Drug Screening Assays, Antitumor
Humans
Inhibitory Concentration 50
KB Cells
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Oleanolic Acid / analogs & derivatives
Oleanolic Acid / chemistry
Oleanolic Acid / isolation & purification*
Oleanolic Acid / pharmacology
Onagraceae / chemistry*
Plants, Medicinal / chemistry*
Stereoisomerism
Taiwan

Substances

Antineoplastic Agents, Phytogenic
coumaroylhederagenin
Oleanolic Acid