New communesin derivatives from the fungus Penicillium sp. derived from the Mediterranean sponge Axinella verrucosa

J Nat Prod. 2004 Jan;67(1):78-81. doi: 10.1021/np030271y.

Abstract

The ethyl acetate extract of Penicillium sp., derived from the Mediterranean sponge Axinella verrucosa, yielded the known compound communesin B (1) and its new congeners communesins C (2) and D (3), as well as the known compounds griseofulvin, dechlorogriseofulvin, and oxaline. All structures were unambiguously established by 1D and 2D NMR and MS data. In several bioassays performed on different leukemia cell lines, the communesins exhibited moderate antiproliferative activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology
  • Artemia / drug effects
  • Drug Screening Assays, Antitumor
  • Griseofulvin / isolation & purification
  • Heterocyclic Compounds, 4 or More Rings / chemistry
  • Heterocyclic Compounds, 4 or More Rings / isolation & purification*
  • Heterocyclic Compounds, 4 or More Rings / pharmacology
  • Humans
  • Italy
  • Mediterranean Sea
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Penicillium / chemistry*
  • Porifera
  • Stereoisomerism
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents
  • Heterocyclic Compounds, 4 or More Rings
  • communesin B
  • communesin C
  • communesin D
  • Griseofulvin