Spirostanol and furostanol glycosides from the fresh tubers of Polianthes tuberosa

J Nat Prod. 2004 Jan;67(1):5-9. doi: 10.1021/np034028a.

Abstract

Six new steroid glycosides--two spirostanols, polianthosides B and C (1, 2), and four furostanols, polianthosides D-G (3-6)--were isolated from the fresh tubers of Polianthes tuberosa, together with seven known spirostanols (7-13) and a known furostanol (14) saponins. Their structures were elucidated on the basis of spectroscopic analysis and the results of acidic and enzymatic hydrolysis. The cytotoxic activities of 1-14 against HeLa cells are reported.

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Asparagaceae / chemistry*
  • Drug Screening Assays, Antitumor
  • Glycosides / chemistry
  • Glycosides / isolation & purification*
  • Glycosides / pharmacology
  • HeLa Cells
  • Humans
  • Hydrolysis
  • Molecular Structure
  • Plants, Medicinal / chemistry*
  • Sterols / chemistry
  • Sterols / isolation & purification*
  • Sterols / pharmacology
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents, Phytogenic
  • Glycosides
  • Sterols