Abstract
Procedure of the synthesis is described for new platinum(IV) drug LA-12 [(OC-6-43)-bis(acetato)(1-adamantylamine)amminedichloroplatinum(IV)]. The X-ray diffraction analysis shows that the structure is created by molecules with octahedral arrangement of ligands around a platinum atom and contains one H(2)O molecule that is not a part of the coordination sphere of platinum. This new drug is more reactive with glutathione than cisplatin and is lacking cross-resistance with cisplatin as proven on the panel of cancer cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amantadine / analogs & derivatives
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Amantadine / chemical synthesis*
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Amantadine / chemistry*
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Amantadine / pharmacology
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Animals
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Cell Line, Tumor
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Cisplatin / pharmacology
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Crystallography, X-Ray
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Drug Resistance, Neoplasm
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Drug Screening Assays, Antitumor
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Humans
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Mice
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Organoplatinum Compounds / chemical synthesis*
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Organoplatinum Compounds / chemistry
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Organoplatinum Compounds / pharmacology
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Structure-Activity Relationship
Substances
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Antineoplastic Agents
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Organoplatinum Compounds
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bis(acetato)(1-adamantylamine)amminedichloroplatinum(IV)
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Amantadine
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Cisplatin