Anti-inflammatory compounds of plant origin. Part I. Action on arachidonic acid pathway, nitric oxide and nuclear factor kappa B (NF-kappaB)

João B Calixto; Michel F Otuki; Adair R S Santos

doi:10.1055/s-2003-45141

Anti-inflammatory compounds of plant origin. Part I. Action on arachidonic acid pathway, nitric oxide and nuclear factor kappa B (NF-kappaB)

Planta Med. 2003 Nov;69(11):973-83. doi: 10.1055/s-2003-45141.

Authors

João B Calixto¹, Michel F Otuki, Adair R S Santos

Affiliation

¹ Department of Pharmacology, CCB, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil. calixto@farmaco.ufsc.br

PMID: 14735432
DOI: 10.1055/s-2003-45141

Abstract

Over the last 10 years, a significant body of evidence has emerged indicating that chemically diverse classes of naturally-occurring substances derived from higher plants are of potential interest for therapeutic interventions in several inflammatory diseases. Part I of this review article focuses on our current knowledge of the mechanisms by which a large range of plant-derived constituents interfere with three relevant targets involved in the inflammatory process, namely arachidonic acid metabolite pathways, nitric oxide and NF-kappaB, and discusses their potential therapeutic use in the management of relevant inflammatory diseases.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
Arachidonic Acid / metabolism*
Humans
NF-kappa B / metabolism*
Nitric Oxide Synthase / metabolism*
Phytotherapy*
Plants, Medicinal*

Substances

Anti-Inflammatory Agents, Non-Steroidal
NF-kappa B
Arachidonic Acid
Nitric Oxide Synthase