Indecent exposure: when telomeres become uncapped

Miguel Godinho Ferreira; Kyle M Miller; Julia Promisel Cooper

doi:10.1016/s1097-2765(03)00531-8

Indecent exposure: when telomeres become uncapped

Mol Cell. 2004 Jan 16;13(1):7-18. doi: 10.1016/s1097-2765(03)00531-8.

Authors

Miguel Godinho Ferreira¹, Kyle M Miller, Julia Promisel Cooper

Affiliation

¹ Telomere Biology Laboratory, Cancer Research UK, 44 Lincoln's Inn Fields, London WC2A 3PX, United Kingdom.

PMID: 14731390
DOI: 10.1016/s1097-2765(03)00531-8

Abstract

The protective "cap" that assembles at chromosome ends recruits and controls an intricate network of biochemical activities, each one critical for telomere structure and the maintenance of genomic stability. Recent studies have uncovered the components of telomere caps and have started to define the pathways that lead from telomere dysfunction to chromosomal catastrophe.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Animals
Chromosome Aberrations
DNA Damage
Humans
Models, Molecular
Saccharomyces cerevisiae Proteins / metabolism
Schizosaccharomyces pombe Proteins / metabolism
Telomerase / metabolism
Telomere / metabolism
Telomere / physiology*

Substances

Saccharomyces cerevisiae Proteins
Schizosaccharomyces pombe Proteins
Telomerase