Information required to manage transplant patients and donors is complex, voluminous and requires the reporting and use of one person's medical information within another person's record. One strategy using a vocabulary model (i.e., LOINC codes with *DONOR specified in the system axes) will lead to problems with combinatorial explosion. After evaluating workflow processes, data collection forms, decision support and functional requirements, we designed and implemented an extendable information model to support the process of care following liver transplantation.