Abstract
To our knowledge, this is the first case report describing progressive multifocal leukoencephalopathy (PML) associated with X-linked agammaglobulinemia. The JC virus was confirmed at autopsy and PML was diagnosed. Humoral immunodeficiency with normal cellular immunity could be infected with JCV.
MeSH terms
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Adult
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Agammaglobulinemia / complications*
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Agammaglobulinemia / diagnosis
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Agammaglobulinemia / genetics
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Biopsy, Needle
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Disease Progression
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Fatal Outcome
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Humans
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Immunohistochemistry
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JC Virus / isolation & purification*
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Leukoencephalopathy, Progressive Multifocal / complications*
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Leukoencephalopathy, Progressive Multifocal / diagnosis*
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Male
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Respiratory Insufficiency
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Risk Assessment
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Severity of Illness Index