Quantitative changes in phospholipids (PL) and fatty acids content (FA) in patients with endometrium hyperplasia have been revealed. During observing endomentrium hyperplasia process we found out on the one hand reliable decrease in phosphatidylethanolamine (PEA), phosphatidylcholine (PC) content and on the other hand increase of its lysoforms. Changes in unsaturated fatty acids (PA n-6)--arachidonic (AA) content and docosahaenoic (DHA) acids content were also shown. The decrease of PC, PEA in patients with endometrium hyperplasia is interrelated with quantitative change of plasmalogenic phospholipids PL, which is too much sensitive to oxidative reactions and at the same time able to protect sells against oxidative stress. Considerable decrease in plasmenyl PEA content on the one side and plasmenyl PC content stability on the other was revealed in patients with endometrium hyperplasia. Above mentioned lipid metabolic derangements of the endometrium are specific with respect to different classes of phospholipids and their fatty acids composition.