Modification of delayed radiation-induced reactions of duodenal vessels and mast cells in old rats

Bull Exp Biol Med. 2003 Oct;136(4):399-403. doi: 10.1023/b:bebm.0000010963.25058.a3.

Abstract

Pronounced ultrastructural changes in vessels and mast cells were observed in duodenal lamina propria of Wistar rats 1 year after single whole-body gamma-irradiation in a dose of 7.5 Gy. Inhibition of adrenocortical function with methopyrone reduced structural damage and improved animal survival.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Animals
  • Catecholamines / metabolism
  • Duodenum / blood supply*
  • Duodenum / drug effects
  • Duodenum / radiation effects*
  • Duodenum / ultrastructure
  • Follow-Up Studies
  • Gamma Rays*
  • Male
  • Mast Cells / drug effects
  • Mast Cells / radiation effects*
  • Mast Cells / ultrastructure
  • Metyrapone / pharmacology
  • Radiation Dosage
  • Radiation Injuries, Experimental / prevention & control*
  • Radiation-Protective Agents / pharmacology
  • Rats
  • Rats, Wistar
  • Time Factors
  • Whole-Body Irradiation

Substances

  • Catecholamines
  • Radiation-Protective Agents
  • Metyrapone