Synthesis of hexahydropyridazine-3-phosphonic acid

Mamoru Kaname; Kazuo Yoshinaga; Yasushi Arakawa; Shigeyuki Yoshifuji

doi:10.1248/cpb.52.160

Synthesis of hexahydropyridazine-3-phosphonic acid

Chem Pharm Bull (Tokyo). 2004 Jan;52(1):160-2. doi: 10.1248/cpb.52.160.

Authors

Mamoru Kaname¹, Kazuo Yoshinaga, Yasushi Arakawa, Shigeyuki Yoshifuji

Affiliation

¹ Faculty of Pharmaceutical Sciences, Hokuriku University, Kanagawa-machi Ho-3, Kanazawa 920-1181, Japan.

PMID: 14709889
DOI: 10.1248/cpb.52.160

Abstract

The synthesis of hexahydropyridazine-3-phosphonic acid (piperidazine-3-phosphonic acid) was performed via a hetero-Diels-Alder reaction followed by Lewis acid-catalyzed phosphonylation. This two-step procedure was improved to a one-pot reaction.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Catalysis
Indicators and Reagents
Magnetic Resonance Spectroscopy
Mass Spectrometry
Organophosphonates / chemical synthesis*
Organophosphonates / chemistry*
Pyridazines / chemistry*
Spectrophotometry, Infrared

Substances

Indicators and Reagents
Organophosphonates
Pyridazines
hexahydropyridazine-3-phosphonic acid