Cytotoxic C-benzylated dihydrochalcones from Uvaria acuminata

Momoyo Ichimaru; Noriyoshi Nakatani; Tomoko Takahashi; Yumi Nishiyama; Masataka Moriyasu; Atsushi Kato; Simon G Mathenge; Francis D Juma; Joseph N Nganga

doi:10.1248/cpb.52.138

Cytotoxic C-benzylated dihydrochalcones from Uvaria acuminata

Chem Pharm Bull (Tokyo). 2004 Jan;52(1):138-41. doi: 10.1248/cpb.52.138.

Authors

Momoyo Ichimaru¹, Noriyoshi Nakatani, Tomoko Takahashi, Yumi Nishiyama, Masataka Moriyasu, Atsushi Kato, Simon G Mathenge, Francis D Juma, Joseph N Nganga

Affiliation

¹ Department of Natural Medicinal Chemistry, Kobe Pharmaceutical University, 4-19-1 Motoyamakita-machi, Higashinada-ku, Kobe 658-8558, Japan. ichimaru@kobepharma-u.ac.jp

PMID: 14709883
DOI: 10.1248/cpb.52.138

Abstract

Two new C-benzylated dihydrochalcones, isochamuvaritin (1) and acumitin (2), have been isolated from the African medicinal plant Uvaria acuminata, together with the previously reported benzylbenzoate (3), uvaretin (4), isouvaretin (5), diuvaretin (6), and uvangoletin (7). The structural elucidation of compounds 1 and 2 in spectroscopic studies is described. C-Benzylated dihydrochalcones, especially 1, 2, 4, and 6, showed considerable cytotoxicity toward human promyelocytic leukemia HL-60 cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / chemistry*
Antineoplastic Agents, Phytogenic / isolation & purification
Antineoplastic Agents, Phytogenic / pharmacology*
Cell Survival / drug effects
Chalcone / chemistry*
Chalcone / isolation & purification
Chalcone / pharmacology*
Chromatography, High Pressure Liquid
HL-60 Cells
Humans
Magnetic Resonance Spectroscopy
Plant Extracts
Plant Roots / chemistry
Spectrometry, Mass, Electrospray Ionization
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
Spectroscopy, Fourier Transform Infrared
Uvaria / chemistry*

Substances

Antineoplastic Agents, Phytogenic
Plant Extracts
Chalcone