Hydrocortisone-induced convulsions

J Toxicol Clin Toxicol. 2003;41(7):995-7. doi: 10.1081/clt-120026524.

Abstract

Glucocorticoids may indirectly cause convulsions by the induction of electrolytes abnormalities, severe hypertension, or severe hyperglycemia. These agents may rarely cause convulsions by a direct toxicity to the central nervous system (CNS). We describe a 23-yr-old patient with Crohn's disease in whom generalized convulsions developed on two occasions while receiving intravenous hydrocortisone.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anti-Inflammatory Agents / administration & dosage
  • Anti-Inflammatory Agents / adverse effects*
  • Anti-Inflammatory Agents / therapeutic use
  • Crohn Disease / drug therapy
  • Female
  • Humans
  • Hydrocortisone / administration & dosage
  • Hydrocortisone / adverse effects*
  • Hydrocortisone / therapeutic use
  • Infusions, Intravenous
  • Seizures / chemically induced*

Substances

  • Anti-Inflammatory Agents
  • Hydrocortisone