Abstract
Nicotine administered acutely at subconvulsive dose of 4 mg/kg, significantly decreased the protective activity of valproate, carbamazepine, diphenylhydantoin, phenobarbital, topiramate and lamotrigine against maximal electroshock-induced tonic convulsions in mice. The obtained data may suggest that interaction between nicotine and antiepileptic drugs should be carefully considered as a cause of the therapeutic failure in epileptic patients.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anticonvulsants / administration & dosage
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Anticonvulsants / antagonists & inhibitors*
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Anticonvulsants / pharmacokinetics
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Carbamazepine / administration & dosage
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Carbamazepine / antagonists & inhibitors
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Carbamazepine / pharmacokinetics
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Dose-Response Relationship, Drug
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Drug Interactions
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Electroshock
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Fructose / administration & dosage
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Fructose / analogs & derivatives*
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Fructose / antagonists & inhibitors
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Fructose / pharmacokinetics
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Humans
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Injections, Intraperitoneal
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Lamotrigine
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Mice
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Nicotine / administration & dosage*
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Nicotine / adverse effects*
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Nicotine / pharmacokinetics
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Phenobarbital / administration & dosage
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Phenobarbital / antagonists & inhibitors
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Phenobarbital / pharmacokinetics
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Phenytoin / administration & dosage
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Phenytoin / antagonists & inhibitors
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Phenytoin / pharmacokinetics
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Seizures / chemically induced
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Seizures / physiopathology
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Seizures / prevention & control
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Topiramate
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Triazines / administration & dosage
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Triazines / antagonists & inhibitors
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Triazines / pharmacokinetics
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Valproic Acid / administration & dosage
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Valproic Acid / antagonists & inhibitors
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Valproic Acid / pharmacokinetics
Substances
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Anticonvulsants
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Triazines
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Topiramate
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Fructose
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Carbamazepine
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Valproic Acid
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Phenytoin
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Nicotine
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Lamotrigine
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Phenobarbital