1-Methyl-3-nitropyridine: an efficient oxidant of NADH in non-enzymatic and enzyme-mediated processes

Free Radic Res. 2003 Nov;37(11):1157-62. doi: 10.1080/10715760310001604161.

Abstract

It is shown that NADH can be effectively oxidized by 1-methyl-3-nitropyridine in non-enzymatic and enzyme-mediated processes. Mechanistic issues of these reactions are discussed. These processes seem to contribute to the observed cytotoxicity of 1-methyl-3-nitropyridine. A key role of 1-methyl-3-nitropyridinyl radical formed in the enzyme-mediated processes is emphasized.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apoptosis
  • Cell Line, Tumor
  • Drug Screening Assays, Antitumor
  • Free Radicals / metabolism
  • Kinetics
  • Leukemia L1210
  • NAD / metabolism*
  • NADH Dehydrogenase / metabolism
  • Oxidants / metabolism
  • Oxidants / pharmacology*
  • Oxidation-Reduction
  • Oxygen / metabolism
  • Pyridinium Compounds / metabolism
  • Pyridinium Compounds / pharmacology*
  • Superoxide Dismutase / metabolism
  • Xanthine Oxidase / metabolism

Substances

  • 1-methyl-3-nitropyridinium
  • Free Radicals
  • Oxidants
  • Pyridinium Compounds
  • NAD
  • Superoxide Dismutase
  • Xanthine Oxidase
  • NADH Dehydrogenase
  • Oxygen