Abstract
Nerve growth factor (NGF) is required for the survival of developing sympathetic and sensory neurons. In the absence of NGF, these neurons undergo protein synthesis-dependent apoptosis. Ten years have gone by since the first reports of specific genes being upregulated during NGF deprivation-induced cell death. Over the last decade, a few additional genes (DP5, Bim, SM-20) have been added to a list that began with cyclin D1 and c-jun. In this chapter, we discuss the evidence that these genes act as regulators of neuronal cell death. We also suggest a hypothesis for how one gene, SM-20, may function to suppress a self-protection mechanism in NGF-deprived neurons.
Publication types
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Historical Article
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Apoptosis Regulatory Proteins
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Cell Death / physiology*
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Cell Division
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Cell Survival / physiology
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Cells, Cultured
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Cyclin D1 / genetics
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Cyclin D1 / metabolism
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Cyclin-Dependent Kinases / metabolism
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DNA-Binding Proteins*
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Dioxygenases
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Gene Expression / physiology*
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History, 20th Century
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History, 21st Century
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Humans
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Hydroxylation
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Hypoxia-Inducible Factor-Proline Dioxygenases
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Immediate-Early Proteins / genetics
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Immediate-Early Proteins / metabolism
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Immunohistochemistry
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Nerve Growth Factors / deficiency*
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Nerve Growth Factors / history
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Nerve Growth Factors / physiology
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Neurons / cytology*
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Neuropeptides / genetics
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Neuropeptides / metabolism
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Nuclear Proteins / metabolism
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Peptide Fragments / metabolism
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Procollagen-Proline Dioxygenase / chemistry
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Procollagen-Proline Dioxygenase / metabolism
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Proto-Oncogene Proteins / metabolism
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Proto-Oncogene Proteins c-jun / genetics
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Proto-Oncogene Proteins c-jun / metabolism
Substances
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Apoptosis Regulatory Proteins
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Bax protein (53-86)
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DNA-Binding Proteins
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HRK protein, human
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Hrk protein, rat
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Immediate-Early Proteins
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Nerve Growth Factors
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Neuropeptides
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Nuclear Proteins
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Peptide Fragments
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Proto-Oncogene Proteins
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Proto-Oncogene Proteins c-jun
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Cyclin D1
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Dioxygenases
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EGLN1 protein, human
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Procollagen-Proline Dioxygenase
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EGLN2 protein, human
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Egln1 protein, mouse
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Hypoxia-Inducible Factor-Proline Dioxygenases
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Cyclin-Dependent Kinases