Discorhabdins S, T, and U, new cytotoxic pyrroloiminoquinones from a deep-water Caribbean sponge of the genus Batzella

J Nat Prod. 2003 Dec;66(12):1615-7. doi: 10.1021/np030292s.

Abstract

Discorhabdins S, T, and U (1-3), three new discorhabdin analogues, have been isolated from a deep-water marine sponge of the genus Batzella. These discorhabdin analogues showed in vitro cytotoxicity against PANC-1, P-388, and A-549 cell lines. The isolation and structure elucidation of discorhabdins S, T, and U are described.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bahamas
  • Cell Line, Tumor
  • Drug Screening Assays, Antitumor
  • Humans
  • Inhibitory Concentration 50
  • Leukemia P388
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Porifera / chemistry*
  • Pyrroles / chemistry
  • Pyrroles / isolation & purification*
  • Pyrroles / pharmacology
  • Quinones / chemistry
  • Quinones / isolation & purification*
  • Quinones / pharmacology
  • Spiro Compounds / chemistry
  • Spiro Compounds / isolation & purification*
  • Spiro Compounds / pharmacology

Substances

  • Pyrroles
  • Quinones
  • Spiro Compounds
  • discorhabdin S
  • discorhabdin T
  • discorhabdin U