Solid-phase synthesis and characterization of a novel fullerene-peptide derived from histone H3

Org Biomol Chem. 2003 Dec 7;1(23):4141-3. doi: 10.1039/b311505d. Epub 2003 Oct 22.

Abstract

A peptide analogue from a histone H3 protein containing the L-fulleropyrrolidino-glutamic acid has been prepared by a solid-phase approach and has been fully characterized. By molecular modelling it was verified that this peptide derivative is able to retain a binding capacity to the MHC (major histocompatibility complex) molecule similar to that of the cognate epitope.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromatography, High Pressure Liquid
  • Epitopes / chemistry
  • Epitopes / immunology
  • Fullerenes / chemistry*
  • Glutamic Acid / chemistry
  • Histones / chemistry*
  • Models, Molecular
  • Molecular Structure
  • Peptides / chemical synthesis*
  • Peptides / chemistry*
  • Peptides / immunology
  • Protein Structure, Tertiary

Substances

  • Epitopes
  • Fullerenes
  • Histones
  • Peptides
  • Glutamic Acid