Abstract
New EPR spin labelled and photoactivatable molecules have been designed to probe specifically the vacuolar-H(+)-ATPase.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkenes / chemical synthesis
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Alkenes / pharmacology*
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Amides / chemical synthesis
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Amides / pharmacology
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Electron Spin Resonance Spectroscopy
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / pharmacology
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Indoles / chemical synthesis
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Indoles / pharmacology*
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Isomerism
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Models, Biological
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Models, Chemical
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Molecular Structure
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Piperidines / chemical synthesis
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Piperidines / pharmacology*
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Spin Labels
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Structure-Activity Relationship
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Temperature
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Vacuolar Proton-Translocating ATPases / antagonists & inhibitors
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Vacuolar Proton-Translocating ATPases / chemistry*
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Vacuolar Proton-Translocating ATPases / metabolism
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Yeasts / drug effects
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Yeasts / enzymology
Substances
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(2Z,4E)-5-(5,6-dichloro-2-indolyl)-2-methoxy-N-(4-(2,2,6,6- tetramethylpiperidinoxy))-2,4-pentadienamide
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Alkenes
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Amides
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Enzyme Inhibitors
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Indoles
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Piperidines
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Spin Labels
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Vacuolar Proton-Translocating ATPases