Abstract
Four novel lysophosphatidylcholine (lysoPC) analogues, (S)-N-stearoyl-O-phosphocholineserine methyl ester [(S)-1a], (R)-1-lyso-2-stearoylamino-2-deoxy-sn-glycero-3-phosphatidylcholine [(R)-2a], (R)-N-stearoyl-O-phosphocholineserine methyl ester [(R)-1b], and (S)-1-lyso-2-stearoylamino-2-deoxy-sn-glycero-3-phosphatidylcholine [(S)-2b], were synthesized starting from serine as a chiral template. These synthetic compounds exhibited greatly enhanced hyphal transition inhibitory activity in Candida as compared to the natural lysoPC.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amphotericin B / pharmacology
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Animals
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Calcium / metabolism
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Candida / drug effects
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Candida / genetics
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Candida / growth & development
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Drug Synergism
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Humans
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Inhibitory Concentration 50
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Lymphocytes / drug effects
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Lymphocytes / metabolism
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Lysophosphatidylcholines / chemical synthesis*
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Lysophosphatidylcholines / chemistry
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Lysophosphatidylcholines / pharmacology
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Microbial Sensitivity Tests
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Serine / chemistry*
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Spleen / cytology
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Spleen / drug effects
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Spleen / metabolism
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Stereoisomerism
Substances
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Lysophosphatidylcholines
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Serine
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Amphotericin B
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Calcium