A tyrosine-modified hypocrellin B with affinity for and photodamaging ability towards calf thymus DNA

Chem Commun (Camb). 2003 Dec 7:(23):2900-1. doi: 10.1039/b309024h.

Abstract

An enhanced photodamaging ability towards CT-DNA was achieved in a tyrosine-modified hypocrellin B by improving the affinity of the sensitizer to DNA.

MeSH terms

  • Animals
  • Binding Sites
  • Cattle
  • DNA / chemistry*
  • DNA / metabolism*
  • DNA Damage / drug effects*
  • DNA Damage / radiation effects*
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Oxygen / metabolism
  • Perylene / analogs & derivatives*
  • Perylene / chemical synthesis
  • Perylene / chemistry*
  • Perylene / metabolism
  • Perylene / pharmacology*
  • Quinones / chemical synthesis
  • Quinones / chemistry*
  • Quinones / metabolism
  • Quinones / pharmacology*
  • Spectrophotometry
  • Tyrosine / chemistry*

Substances

  • Quinones
  • Tyrosine
  • Perylene
  • DNA
  • calf thymus DNA
  • Oxygen
  • hypocrellin B