Abstract
An enhanced photodamaging ability towards CT-DNA was achieved in a tyrosine-modified hypocrellin B by improving the affinity of the sensitizer to DNA.
MeSH terms
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Animals
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Binding Sites
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Cattle
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DNA / chemistry*
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DNA / metabolism*
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DNA Damage / drug effects*
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DNA Damage / radiation effects*
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Oxygen / metabolism
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Perylene / analogs & derivatives*
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Perylene / chemical synthesis
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Perylene / chemistry*
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Perylene / metabolism
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Perylene / pharmacology*
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Quinones / chemical synthesis
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Quinones / chemistry*
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Quinones / metabolism
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Quinones / pharmacology*
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Spectrophotometry
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Tyrosine / chemistry*
Substances
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Quinones
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Tyrosine
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Perylene
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DNA
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calf thymus DNA
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Oxygen
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hypocrellin B