Synthesis of 2-(3'-azido- and 3'-amino-3'-deoxy-beta-D-ribofuranosyl)thiazole-4-carboxamide

Nucleosides Nucleotides Nucleic Acids. 2003 Nov;22(11):2039-48. doi: 10.1081/NCN-120026405.

Abstract

In view of biological activities of tiazofurin and azido or aminosugar nucleosides, novel azido- and amino-substituted tiazofurin derivatives (1 and 2) were efficiently synthesized starting from 1,2;5,6-di-O-isopropylidene-D-glucose.

MeSH terms

  • Animals
  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / pharmacology
  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology
  • Nucleosides / chemical synthesis
  • Nucleosides / pharmacology
  • Ribavirin / analogs & derivatives*
  • Ribavirin / chemical synthesis*
  • Ribavirin / chemistry
  • Ribavirin / pharmacology

Substances

  • Antineoplastic Agents
  • Enzyme Inhibitors
  • Nucleosides
  • Ribavirin
  • tiazofurin