Abstract
We report on a patient affected by ICF syndrome (immunodeficiency, centromeric instability of chromosomes 1, 9 and 16 and facial dysmorphism), who presented with slowing in mentation, mild right hemiparesis and focal motor seizures. MRI study of the brain suggested a diagnosis of progressive multifocal leukoencephalopathy (PML), which was confirmed by JC virus DNA detection on CSF by polymerase chain reaction (PCR). This is a unique case of adult infective neurological complication described in ICF Syndrome.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Acquired Immunodeficiency Syndrome / cerebrospinal fluid
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Acquired Immunodeficiency Syndrome / complications*
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Acquired Immunodeficiency Syndrome / virology
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Adult
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DNA / metabolism
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Female
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Humans
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JC Virus / genetics
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JC Virus / isolation & purification
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Leukoencephalopathy, Progressive Multifocal / cerebrospinal fluid
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Leukoencephalopathy, Progressive Multifocal / complications*
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Leukoencephalopathy, Progressive Multifocal / virology
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Magnetic Resonance Imaging
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Polymerase Chain Reaction / methods