Circulating matrix metalloproteinase-1 and -3 in patients with an acute coronary syndrome

Teruo Inoue; Toru Kato; Kan Takayanagi; Toshihiko Uchida; Isao Yaguchi; Hirotoshi Kamishirado; Shigenori Morooka; Nobuo Yoshimoto

doi:10.1016/j.amjcard.2003.08.061

Circulating matrix metalloproteinase-1 and -3 in patients with an acute coronary syndrome

Am J Cardiol. 2003 Dec 15;92(12):1461-4. doi: 10.1016/j.amjcard.2003.08.061.

Authors

Teruo Inoue¹, Toru Kato, Kan Takayanagi, Toshihiko Uchida, Isao Yaguchi, Hirotoshi Kamishirado, Shigenori Morooka, Nobuo Yoshimoto

Affiliation

¹ Department of Cardiology, Koshigaya Hospital, Dokkyo University School of Medicine, Koshigaya, Saitama, Japan. inouet@dokkyomed.ac.jp

PMID: 14675588
DOI: 10.1016/j.amjcard.2003.08.061

Abstract

To elucidate the diagnostic value of serum matrix metalloproteinase (MMP) levels, we measured MMP-1 and MMP-3 by a 1-step sandwich enzyme immunoassay. The transcardiac gradients of both MMPs were greater in patients with unstable angina and acute myocardial infarction than in patients with stable effort angina or control patients. Serum MMP levels appear to be a marker of plaque instability in patients with acute coronary syndrome.

MeSH terms

Angina Pectoris / blood*
Angina, Unstable / blood*
Biomarkers / blood
Case-Control Studies
Coronary Angiography
Female
Humans
Immunoenzyme Techniques
Male
Matrix Metalloproteinase 1 / blood*
Matrix Metalloproteinase 3 / blood*
Middle Aged
Myocardial Infarction / blood*
Tissue Inhibitor of Metalloproteinase-1 / blood

Substances

Biomarkers
Tissue Inhibitor of Metalloproteinase-1
Matrix Metalloproteinase 3
Matrix Metalloproteinase 1