Botulinum toxin in the treatment of axillary hyperhidrosis

Skinmed. 2003 Jul-Aug;2(4):209-11. doi: 10.1111/j.1540-9740.2003.02451.x.

Abstract

Introduction: Axillary hyperhidrosis can be a source of social isolation and embarrassment. The available treatments are either ineffective or have intolerable side effects. The search for a simple, long-lasting, and safe treatment has led to the use of botulinum-A toxin injections in those with excessive axillary hyperhidrosis.

Materials and methods: Fifteen patients participated in this study. All had a history of axillary hyperhidrosis of 1-6 years duration and were using different types of therapies without any benefit. Each patient was injected intradermally with 125 units of botulinum-A toxin (Dysport, Spenywood Pharmaceutical) in 5-6 points over an elliptical area on each side. Patient follow-up was performed using the iodine-starch test.

Results: A total of 14 out of the 15 patients had complete anhidrosis 1 week after the injection. This result lasted for periods ranging from 1-6 months. No side effects were encountered.

Conclusion: Intradermal injection of botulinum-A toxin seems to be a safe, rapid, and effective method of treatment in axillary hyperhidrosis.

Publication types

  • Clinical Trial

MeSH terms

  • Adolescent
  • Adult
  • Axilla
  • Botulinum Toxins, Type A / therapeutic use*
  • Female
  • Humans
  • Hyperhidrosis / drug therapy*
  • Male
  • Neuromuscular Agents / therapeutic use*
  • Treatment Outcome

Substances

  • Neuromuscular Agents
  • Botulinum Toxins, Type A