Abstract
The mammalian cell surface is a highly heterogeneous chemical environment with proteins, carbohydrates, lipids and composite molecules controlling vital cell functions. Chemical modification of this environment is a challenge due to the complexity of the surface chemistry and the fragility of the cell. Here, we review recent attempts to perform targeted, non-genetically controlled, changes to cell surface chemistry. Potential applications of cell surface engineering are presented.
MeSH terms
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Animals
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Carbohydrate Sequence
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Cell Aggregation / drug effects
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Cell Aggregation / physiology
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Cell Membrane / chemistry*
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Cell Membrane / metabolism*
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Cholesterol / analogs & derivatives
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Cholesterol / metabolism
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Glycoconjugates / metabolism
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Glycosylation
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Glycosyltransferases / metabolism
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Molecular Sequence Data
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N-Acetylneuraminic Acid / metabolism
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Polyethylene Glycols / chemistry
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Receptors, Cell Surface / metabolism
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Surface Properties
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Tissue Engineering / methods
Substances
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Glycoconjugates
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Receptors, Cell Surface
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Polyethylene Glycols
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Cholesterol
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Glycosyltransferases
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N-Acetylneuraminic Acid