Synthesis of molecularly imprinted polymer with 7-chloroethyl-theophylline-immobilized silica gel as template and its molecular recognition function

Spectrochim Acta A Mol Biomol Spectrosc. 2004 Jan;60(1-2):241-4. doi: 10.1016/s1386-1425(03)00225-7.

Abstract

By reaction of 7-chloroethyl-theophylline with aminopropylsilanized silica gel we synthesized a 7-chloroethyl-theophylline-immobilized silica gel as template molecule and prepared a molecularly imprinted polymer (MIP-Si), which had special recognition sites to 7-chloroethyl-theophylline. A conventional molecularly imprinted polymer (MIP) using 7-chloroethyl-theophylline as template was also prepared for comparison. Binding abilities to 7-chloroethyl-theophylline and its structural analogs revealed that the MIP-Si shows much higher binding speed and much more binding capacity than the MIP does.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Dimerization
  • Fluorescent Dyes / pharmacology
  • Luminescence
  • Microscopy, Electron, Scanning
  • Models, Chemical
  • Polymers / chemistry*
  • Protein Binding
  • Silicon / chemistry*
  • Spectrometry, Fluorescence
  • Spectrophotometry / methods*
  • Theophylline / analogs & derivatives*
  • Theophylline / chemistry*
  • Time Factors
  • Ultraviolet Rays

Substances

  • Fluorescent Dyes
  • Polymers
  • Theophylline
  • 7-(2-chloroethyl)theophylline
  • Silicon