Anti-myeloperoxidase (anti-MPO) associated vasculitis can result in rapid clinical deterioration. Immunosuppressive therapy is effective but involving considerable toxicity, and disease relapse frequently ensues. Laboratory parameters, such as C-reactive protein and anti-MPO titer, have substantial values in monitoring disease activity. However, the sensitivity and specificity are not satisfactory. This report presents the case of an old man with anti-MPO associated vasculitis. A parallel correlation between serum VEGF levels with C-reactive protein and anti-MPO titer was clearly demonstrated, implying a promising role of VEGF on monitoring disease activity in anti-MPO associated vasculitis. This is the first description of a correlation between VEGF and anti-MPO associated vasculitis.