A 43-year-old men with hemophilia A was admitted to CCU due to anginal pain lasting for sixteen hours. ECG revealed anterior wall myocardial infarction and elevated CK and MB-CK levels confirmed the diagnosis. Exercise test performed later was positive and the patient underwent elective coronary angiography which showed 90% stenosis of left anterior descending (LAD) and closed circumflex coronary artery. Next, angioplasty of LAD, preceded by antihemophilic globulin (factor VIII) administration, was successfully performed.