The FEMA GRAS assessment of cinnamyl derivatives used as flavor ingredients

Food Chem Toxicol. 2004 Feb;42(2):157-85. doi: 10.1016/j.fct.2003.08.021.

Abstract

This publication is the seventh in a series of safety evaluations performed by the Expert Panel of the Flavor and Extract Manufacturers Association (FEMA). In 1993, the Panel initiated a comprehensive program to re-evaluate the safety of more than 1700 GRAS flavoring substances under conditions of intended use. Elements that are fundamental to the safety evaluation of flavor ingredients include exposure, structural analogy, metabolism, pharmacokinetics and toxicology. Flavor ingredients are evaluated individually and in the context of the available scientific information on the group of structurally related substances. Scientific data relevant to the safety evaluation of the use of cinnamyl derivatives as flavoring ingredients is evaluated.

Publication types

  • Review

MeSH terms

  • Acrolein / analogs & derivatives*
  • Acrolein / chemistry
  • Acrolein / pharmacokinetics
  • Acrolein / toxicity
  • Animals
  • Cinnamates / chemistry
  • Cinnamates / pharmacokinetics
  • Cinnamates / toxicity
  • Flavoring Agents / chemistry
  • Flavoring Agents / pharmacokinetics*
  • Flavoring Agents / toxicity
  • Food Additives / standards*
  • Food Industry
  • Humans
  • Lethal Dose 50
  • Propanols / chemistry
  • Propanols / pharmacokinetics*
  • Propanols / toxicity
  • Rats
  • Safety*
  • Toxicity Tests

Substances

  • Cinnamates
  • Flavoring Agents
  • Food Additives
  • Propanols
  • cinnamic acid
  • Acrolein
  • cinnamaldehyde
  • cinnamyl alcohol