Abstract
Thiosemicarbazides undergo different cyclization reactions to give five membered heterocycles. The product of cyclization depends on the reagent used. This cyclization leads to the formation of 1,3,4-oxadiazole, 1,3,4-thiadiazole and 1,2,4-triazole derivatives. The reaction of thioglycolyl hydrazide derivatives of the 1,2,4-triazole compounds was discussed. The activity against hepatitis B virus (HBV) has been tested.
MeSH terms
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Antiviral Agents / chemical synthesis*
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Antiviral Agents / pharmacology*
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Cell Line
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Cell Survival / drug effects
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Drug Screening Assays, Antitumor
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Enzyme-Linked Immunosorbent Assay
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Hepatitis B virus / drug effects
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Humans
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Indicators and Reagents
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Magnetic Resonance Spectroscopy
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Methylation
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Oxazoles / chemical synthesis*
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Oxazoles / pharmacology*
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Reverse Transcriptase Polymerase Chain Reaction
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Thiazoles / chemical synthesis*
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Thiazoles / pharmacology*
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Triazoles / chemical synthesis*
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Triazoles / pharmacology*
Substances
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Antiviral Agents
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Indicators and Reagents
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Oxazoles
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Thiazoles
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Triazoles