[Barrett's esophagus: endoscopic treatment of high-grade dysplasia and early cancer]

Ned Tijdschr Geneeskd. 2003 Nov 15;147(46):2275-81.
[Article in Dutch]

Abstract

In a Barrett's oesophagus without dysplasia, endoscopic control every 3-5 years is sufficient. If low-grade dysplasia is encountered in the surveillance biopsies, then endoscopy should be repeated within 3-6 months and yearly thereafter if the low-grade dysplasia persists. Antacid medication must be prescribed in cases with extensive inflammation. The endoscopic treatment of patients with high-grade dysplasia and/or early cancer of the mucosa in a Barrett's oesophagus (tissue ablation and/or mucosa resection) seems a promising alternative to surgery in view of the combination of effectiveness, limited invasiveness compared to surgical resection, and the preservation of a functional oesophagus. Data from long-term follow-up are still limited. Strict endoscopic surveillance will probably detect metachronic abnormalities in an early and still curable stage, creating a new opportunity for endoscopic treatment.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Barrett Esophagus / pathology
  • Barrett Esophagus / surgery*
  • Biopsy
  • Esophageal Neoplasms / pathology
  • Esophageal Neoplasms / surgery*
  • Esophagoscopy / methods*
  • Esophagus / pathology
  • Humans
  • Neoplasm Staging
  • Precancerous Conditions / pathology
  • Precancerous Conditions / surgery*