Evidence from engineered gene fusions for the repeated use of a module in a modular polyketide synthase

Chem Commun (Camb). 2003 Nov 21:(22):2780-2. doi: 10.1039/b310648a.

Authors

Carlos Olano¹, Barrie Wilkinson, Steven J Moss, Alfredo F Braña, Carmen Méndez, Peter F Leadlay, José A Salas

Affiliation

¹ Departamento de Biología Funcional e Instituto Universitario de Oncologia del Principado de Asturias, Universidad de Oviedo, 33006 Oviedo, Spain.

PMID: 14651102
DOI: 10.1039/b310648a

Abstract

Functional evidence for programmed loss of co-linearity on the borrelidin modular polyketide synthase (PKS) is presented.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Artificial Gene Fusion*
Base Sequence
Fatty Alcohols / chemistry
Fatty Alcohols / metabolism
Genetic Engineering*
Protein Structure, Tertiary

Substances

Fatty Alcohols
borrelidin