Telomestatin-induced stabilization of the human telomeric DNA quadruplex monitored by electrospray mass spectrometry

Frédéric Rosu; Valérie Gabelica; Kazuo Shin-ya; Edwin De Pauw

doi:10.1039/b309394h

Telomestatin-induced stabilization of the human telomeric DNA quadruplex monitored by electrospray mass spectrometry

Chem Commun (Camb). 2003 Nov 7:(21):2702-3. doi: 10.1039/b309394h.

Authors

Frédéric Rosu¹, Valérie Gabelica, Kazuo Shin-ya, Edwin De Pauw

Affiliation

¹ Department of Chemistry, University of Liege, Sart-Tilman Bat. B6c, B-4000 Liège, Belgium.

PMID: 14649819
DOI: 10.1039/b309394h

Abstract

Electrospray mass spectrometry (ESI-MS) was used to monitor the kinetics of duplex formation between the human telomeric DNA quadruplex and its complementary strand; the complexation of telomestatin to the G-quadruplex delays the unwinding of the quadruplex structure and formation of the duplex.

MeSH terms

DNA / chemistry*
G-Quadruplexes
Humans
Kinetics
Models, Molecular
Nucleic Acid Conformation
Nucleic Acid Denaturation
Oligonucleotides / chemistry
Oxazoles / chemistry*
Spectrometry, Mass, Electrospray Ionization
Telomere / chemistry*
Temperature

Substances

Oligonucleotides
Oxazoles
telomestatin
DNA