Abstract
Objective:
To study the liver-protection and promoting bile secretion of ursolic acid.
Methods:
Ursolic acid was administrated to the mice with liver injury induced by CCl4 or APIT. ALT, AST levels in serum were examined. The bile flow rate and the concentration of the main components in the bile of rats administrated with ursolic acid were estimated.
Results:
Ursolic acid could decrease the serum ALT, AST, SB levels in the mice treated with CCl4 or APIT, promote the secretion of bile and increase the concentration of bilirubin in the bile.
Conclusion:
Ursolic acid exhibited significant liver protection and promoting blie secretion.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alanine Transaminase / blood
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Animals
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Aspartate Aminotransferases / blood
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Bile / metabolism*
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Carbon Tetrachloride Poisoning
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Chemical and Drug Induced Liver Injury / etiology
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Chemical and Drug Induced Liver Injury / pathology*
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Chemical and Drug Induced Liver Injury / physiopathology
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Drugs, Chinese Herbal / isolation & purification
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Drugs, Chinese Herbal / pharmacology
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Female
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Isothiocyanates
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Liver / pathology
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Male
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Mice
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Plants, Medicinal / chemistry
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Protective Agents / isolation & purification
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Protective Agents / pharmacology*
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Random Allocation
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Rats
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Rats, Wistar
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Sambucus / chemistry
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Triterpenes / isolation & purification
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Triterpenes / pharmacology*
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Ursolic Acid
Substances
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Drugs, Chinese Herbal
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Isothiocyanates
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Protective Agents
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Triterpenes
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phenethyl isothiocyanate
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Aspartate Aminotransferases
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Alanine Transaminase