The effects of dopamine administration on the adrenal gland of a lizard, Podarcis sicula, are described. Dopamine (0.7mg/100g body wt/day for 4 consecutive days) raised plasma ACTH and corticosterone levels (ACTH: from the basal level of 4.40+/-0.05-7.30+/-0.08pg/ml 24h after the fourth dopamine injection; corticosterone: from 3.59+/-0.03ng/ml in untreated lizards to 7.40+/-0.05ng/ml 24h after the fourth dopamine injection), showing a stimulatory effect on the pituitary-interrenal axis activity. In the chromaffin tissue dopamine apparently enhanced the activity of PNMT enzyme; in fact a strong raise in the number of adrenaline cells and a decrease in the number of noradrenaline cells were observed, decreasing the numeric NA/A cell ratio, from 1.4/1 of control specimens to 0.5/1 24h after the fourth dopamine injection. At EM level, chromaffin cells contained both NA and A granules, as well as very clear granules (CG); CG granules showed granular elements ranging between 340 and 347A in diameter. These cells might be the morphological expression of a process of catecholamine resynthesis, due to a possible increase in catecholamine release, following exposure to dopamine.