Synthetic developments towards PNA-peptide conjugates

Martijn C de Koning; Gijs A van der Marel; Mark Overhand

doi:10.1016/j.cbpa.2003.10.006

Synthetic developments towards PNA-peptide conjugates

Curr Opin Chem Biol. 2003 Dec;7(6):734-40. doi: 10.1016/j.cbpa.2003.10.006.

Authors

Martijn C de Koning¹, Gijs A van der Marel, Mark Overhand

Affiliation

¹ Leiden Institute of Chemistry, Leiden University, PO Box 9502, 2300 RA Leiden, The Netherlands.

PMID: 14644183
DOI: 10.1016/j.cbpa.2003.10.006

Abstract

Since the discovery of peptide nucleic acids (PNAs) as DNA mimics in the early 1990s, a tremendous effort has been directed to their application as antisense and antigene probes. With the aim of further enhancing their properties, PNAs have been conjugated to a variety of effector molecules. Among these, small peptide fragments, often derived from functional proteins, are able to convey their specific properties to the conjugate.

Publication types

Review

MeSH terms

Ligands
Peptide Nucleic Acids / chemical synthesis*
Peptide Nucleic Acids / chemistry
Peptides / chemical synthesis*
Peptides / chemistry

Substances

Ligands
Peptide Nucleic Acids
Peptides