Abstract
A new cucurbitacin D analogue, 2-deoxycucurbitacin D (1), as well as cucurbitacin D (2) and 25-acetylcucurbitacin F (3) were isolated from Sloanea zuliaensis. Compound 1 was found only in the young leaves of the plant and not in the mature leaves, and its structure was established using spectroscopic means. Compounds 1-3 demonstrated potent cytotoxic activity against breast (MCF-7), lung (H-460), and central nervous system (SF-268) human cancer cell lines.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Breast Neoplasms
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Central Nervous System Neoplasms
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Drug Screening Assays, Antitumor
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Elaeocarpaceae / chemistry*
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Female
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Humans
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Lung Neoplasms
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Molecular Structure
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Panama
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Plant Leaves / chemistry
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Plants, Medicinal / chemistry*
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Triterpenes / chemistry
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Triterpenes / isolation & purification*
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Triterpenes / pharmacology
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Tumor Cells, Cultured / drug effects
Substances
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2-deoxycucurbitacin D
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Antineoplastic Agents, Phytogenic
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Triterpenes
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cucurbitacin D