Cytotoxic cucurbitacin constituents from Sloanea zuliaensis

J Nat Prod. 2003 Nov;66(11):1515-6. doi: 10.1021/np0303106.

Abstract

A new cucurbitacin D analogue, 2-deoxycucurbitacin D (1), as well as cucurbitacin D (2) and 25-acetylcucurbitacin F (3) were isolated from Sloanea zuliaensis. Compound 1 was found only in the young leaves of the plant and not in the mature leaves, and its structure was established using spectroscopic means. Compounds 1-3 demonstrated potent cytotoxic activity against breast (MCF-7), lung (H-460), and central nervous system (SF-268) human cancer cell lines.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Breast Neoplasms
  • Central Nervous System Neoplasms
  • Drug Screening Assays, Antitumor
  • Elaeocarpaceae / chemistry*
  • Female
  • Humans
  • Lung Neoplasms
  • Molecular Structure
  • Panama
  • Plant Leaves / chemistry
  • Plants, Medicinal / chemistry*
  • Triterpenes / chemistry
  • Triterpenes / isolation & purification*
  • Triterpenes / pharmacology
  • Tumor Cells, Cultured / drug effects

Substances

  • 2-deoxycucurbitacin D
  • Antineoplastic Agents, Phytogenic
  • Triterpenes
  • cucurbitacin D