Abstract
The synthesis of a new series of 1 beta-methylcarbapenems containing a substituted imidazolino pyrrolidine moiety is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of the substituent on the imidazoline ring was investigated. Compound 13 g which has a N-sulfonylmethyl substituted imidazoline moiety showed the most potent antibacterial activity.
MeSH terms
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology
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Carbapenems / chemical synthesis*
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Carbapenems / chemistry
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Carbapenems / pharmacology
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Drug Stability
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Gram-Negative Bacteria / drug effects
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Gram-Positive Bacteria / drug effects
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Microbial Sensitivity Tests
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Molecular Structure
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Pyrrolidines / chemical synthesis*
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Pyrrolidines / chemistry
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Pyrrolidines / pharmacology
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Structure-Activity Relationship
Substances
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Anti-Bacterial Agents
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Carbapenems
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Pyrrolidines