Enhanced phagocytosis of Candida species mediated by opsonization with a recombinant human antibody single-chain variable fragment

Infect Immun. 2003 Dec;71(12):7228-31. doi: 10.1128/IAI.71.12.7228-7231.2003.

Abstract

Specific antibody opsonization significantly enhances the level of phagocytosis of Candida in the absence of complement. Furthermore, we have described a system using a recombinant human antibody single-chain variable fragment that allows a comparative study of phagocytosis of multiple Candida species opsonized via a common antigen.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antibodies, Fungal / genetics
  • Antibodies, Fungal / immunology
  • Candida / classification*
  • Candida / immunology*
  • Humans
  • Immunoglobulin Fragments / genetics
  • Immunoglobulin Fragments / immunology*
  • Immunoglobulin Variable Region
  • Monocytes / immunology
  • Neutrophils / immunology
  • Opsonin Proteins / metabolism*
  • Phagocytosis*
  • Recombinant Proteins / immunology*

Substances

  • Antibodies, Fungal
  • Immunoglobulin Fragments
  • Immunoglobulin Variable Region
  • Opsonin Proteins
  • Recombinant Proteins